منابع مشابه
IAP survivin regulates atherosclerotic macrophage survival.
OBJECTIVES Inflammatory macrophage apoptosis is critical to atherosclerotic plaque formation, but its mechanisms remain enigmatic. We hypothesized that inhibitor of apoptosis protein (IAP) survivin regulates macrophage death in atherosclerosis. METHODS AND RESULTS Western blot analysis revealed discrete survivin expression in human aorta lipid streaks but virtually none in advanced atheroscle...
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From the realization that cell number homoeostasis is fundamental to the biology of all metazoans, and that deregulation of this process leads to human diseases, enormous interest has been devoted over the last two decades to map the requirements of cell death and cell survival. This effort has led to tangible progress, and we can now chart with reasonable accuracy complex signalling circuitrie...
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A signaling cascade termed the “spindle checkpoint” monitors interactions between the kinetochores of chromosomes and spindle microtubules to prevent precocious separation of sister chromatids. We have investigated the role of human inhibitor of apoptosis protein (IAP) survivin in regulation of cell division. We demonstrate that HeLa and PtK1 cells transfected or microinjected with survivin ant...
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See related article, pages 235–240. In 1989, the Copenhagen AFASAK study1 reported results from the first randomized, placebo-controlled trial evaluating adjusted-dose warfarin and aspirin in the prevention of stroke for nonvalvular atrial fibrillation (NVAF). Like the 5 randomized, placebo-controlled trials that came after it,2 the Copenhagen AFASAK study demonstrated a reduction in embolic ev...
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HTTPS is the de facto standard for securing Internet communications. Although it is widely deployed, the security provided with HTTPS in practice is dubious. HTTPS may fail to provide security for multiple reasons, mostly due to certificate-based authentication failures. Given the importance of HTTPS, we investigate the current scale and practices of HTTPS and certificate-based deployment. We p...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2015
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2014.12.007